Advances in the Study of the Interspecific Interaction Between Respiratory Pathogens Mediated by Pseudomonas aeruginosa Quorum-Sensing System
Abstract：Bacterial chronic respiratory infections are common diseases that threaten the health of people worldwide and restrict social and economic development. The complexity of respiratory tract environment and structure frequently lead to the colonization of a variety of bacterial pathogens, such as
Pseudomonas aeruginosa,
Staphylococcus aureus,
Escherichia coli,
Klebsiella pneumoniae,
Acinetobacter baumannii, and
Candida albicans. These pathogens evolve complex interspecific relationships including cooperation, competition, and symbiosis as chronic lung infection progress. By forming a relatively stable community system, multiple pathogens can integrate to cope with the harsh living conditions of the respiratory tract, resulting in the failure of targeted treatment or recurrence of respiratory infections. At present, revealing the underlying interaction mechanism among coexisting bacterial pathogens is an emerging subject, and clinical evidences have indicated that the colonization of
P. aeruginosa is closely related to the development of chronic respiratory infections, and this microorganism can use elaborate quorum-sensing system to dominate the growth and coexistence of other pathogens. Therefore, this paper reviews the interspecific relationship and interaction mechanism between
P. aeruginosa and other common respiratory infection pathogens mediated by the quorum-sensing system, and this can facilitate the understanding of the correlation between pathogen-pathogen interactions and chronic respiratory infections, and provide new perspectives and directions for further improvement of clinical treatment programs, disease control and the development of novel anti-infective drugs.
2019,38(4): 472-480 收稿日期：2019-03-14
分类号：Q939.1;R378
基金项目：国家自然科学基金青年基金项目（31700111）；四川省科学技术协会青年人才托举工程项目（2018RCTJ）
作者简介：袁阳(1995-),男,硕士,研究方向:病原菌互作机制
*通信作者:赵克雷,E-mail:zkl5228@163.com
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