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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
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Your Position :Home->Past Journals Catalog->2015 Vol.34 No.1

Comparison of Three Kinds of Type Constipation Model
Author of the article:HUANG Xiaoli, CHEN Lin, CHEN Chen, ZHANG Lei, LIU Wan, HU Rong*, KONG Guimei, BO Ping*, DONG Xiaoyun, WANG Jun
Author's Workplace:School of Medicine, Yangzhou University, Yangzhou, Jiangsu Province 225001, China
Key Words:constipation model; loperamide; sucralfate; rats; mice; gender
Abstract:Objective To compare the effects of different methods including different drugs, different animals and different gender on the establishment of the constipation mouse model. Methods A total of 48 ICR mice (half males and half females) were randomly divided into six groups (female/male control group, female/male loperamide group, and female/male sucralfate group). Besides, 24 Wistar rats (half males and half females) were randomly divided into four groups (female/male control group and female/male loperamide group). The mice of loperamide group were fed with loperamide twice a day, and the mice of sucralfate group were fed with sucralfate once a day. Then the constipation model was evaluated by the indices of body weight, food and water intake, fecal water content, transfer time between mouth and anal versus distal colon histology. Results Significant differences were observed between the control groups and corresponding experiment groups in body weight, fecal water content, transfer time, and anal versus distal colon histology. Differences between the two drugs were not significant. Conclusion The loperamide-induced constipation in female animal was the best model.
2015,34(1): 111-116 收稿日期:2014-7-15
DOI:10.3969/j.issn.1000-7083.2015.01.020
分类号:Q95-33
基金项目:国家自然科学基金项目(81173392)
作者简介:黄小丽(1990-),女,硕士研究生,研究方向为中药制剂,E-mail:951686312@qq.com
*通讯作者:卜平,男,博士,教授,E-mail:boping@yzu.edu.cn;胡荣,女,博士,教授,E-mail:398563432@qq.com
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