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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
Address:College of Life Sciences, Sichuan University, No.29, Wangjiang Road, Chengdu, Sichuan Province, 610064, China
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Your Position :Home->Past Journals Catalog->2014 Vol.33 No.6

Expression and Localization of Aquaporins in Bactrian Camel Lung
Author of the article:QIN Song, LI Haiyan, LIU Jianfeng, SHAO Baoping, WANG Jianlin*
Author's Workplace:(College of Life Science, Lanzhou University, Lanzhou 730000, China)
Key Words:aquaporins (AQPs); Bactrian camel (Camelus bactrianus); lung; immunohistochemistry
Abstract:Objective  In order to provide a molecular basis for the adaptation mechanism of Bactrian camel (Camelus bactrianus) to the extremely arid environment, the respiratory morphological characteristics of bactrian camel lung and the expression of aquaporins were determined in this study. Methods  Paraffin sections and statistical methods were used to study the structure and ultrastructure morphology. And the immunohistochemical methods were used to analyze the expression and localization of aquaporins in the lung. Results  Bactrian camel had a long and curved tracheal, and the lung was more compact and had higher water than cattle. Immunohistochemical detection results showed that there were four aquaporins, including AQP1, AQP3, AQP4 and AQP5 in the lung of the bactrian camel. AQP1 was mainly expressed in the capillary network of respiratory tract and tracheal epithelial cells in the apical membrane surface. AQP3 was present on the surface of respiratory epithelial and the basement membranes of gland cells. AQP4 was distributed throughout the basolateral membranes of the airway epithelial goblet cells and the alveolar epithelial cells . AQP5 was distributed on the luminal surface of the gland glandular cells and the alveolar epithelial cells . Strong expression of aquaporins in the lung of the bactrian camel were related to the physiological function, such as airway humidification and water balance, airway surface liquid regulation and control, lung fluid transportation and water balance in lung et al., which provided a molecular biological explanation.
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