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Issue:ISSN 1000-7083
          CN 51-1193/Q
Director:Sichuan Association for Science and Technology
Sponsored by:Sichuan Society of Zoologists; Chengdu Giant Panda Breeding Research Foundation; Sichuan Association of Wildlife Conservation; Sichuan University
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Effects of isoliquiritigenin on the Embryonic development,angiogenesis and heart in zebrafish embryos
Author of the article:HE Junlin, YU Si, CAO Zhixing, WANG Wenwen, ZHANG Ruoqi, LI Yuzhi, PENG Cheng
Author's Workplace:Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine
Key Words:Isoliquiritigenin; Zebrafish embryos; Angiogenesis; Heart rate; Cardiac morphology
Abstract:Objective To study the effects of isoliquiritigenin on zebrafish embryonic development, angiogenesis and heart function. Methods After treatment for 12, 24, 36, 48 h separately, the effect of isoliquiritigenin on 10 and 24 hour post fertilization development, angiogenesis and cardiac morphology was investigated and recorded with microscope. Results Isoliquiritigenin inhibited the development of zebrafish embryos tail slightly at 4 μg.ml-1, and severely at 12 μg.ml-1; Isoliquiritigenin significantly inhibited the angiogenesis of zebrafishes at 2 μg.ml-1, and even completely inhibited the angiogenesis at 8 μg.ml-1 ; At the low or medium doses, Isoliquiritigenin reduced the heart rate of zebrafish embryos firstly and then increased it, without influence on cardiac morphology. At the high doses, isoliquiritigenin disturbed the heart development of zebrafish, and caused the zebrafish’s pericardium and saccus omphaloentericus swelling. Conclusions Isoliquiritigenin has a good effect on anti-angiogenesis and slowing down the heart rate at the low or medium doses, but inhabits the development of zebrafish embryos at the high doses.
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